What’s the best set of characters to play with?

What do you think is the best 4 characters to use in a round? I absolutely have some favorite characters, but they usually only interact with like one other person most of the time, and Id love to know the best group to use. (Personally looking for mostly women, and I’m more so interested in people from different franchises since of course the main cast of a show is going to work well with each other)